Polycystic ovary syndrome (PCOS) is one of the most common hormonal disorders affecting people with ovaries — estimated to affect 8–13% of reproductive-age women globally, with up to 70% undiagnosed. It's associated with irregular periods, excess androgens, and characteristic ovarian appearance on ultrasound, but it's actually a metabolic condition that affects the whole body, not just the reproductive system.
What Is PCOS?
PCOS is a complex hormonal and metabolic disorder characterised by a cluster of symptoms — not a single disease. Its name is a bit misleading: "polycystic ovaries" describes a specific ultrasound appearance (many small follicles), but you don't need polycystic ovaries to have PCOS, and having polycystic-looking ovaries doesn't mean you have PCOS.
At its core, PCOS involves disrupted ovulation, often driven by insulin resistance and elevated androgen (male hormone) levels. These hormonal imbalances create a cascade of effects throughout the body.
How Is PCOS Diagnosed? The Rotterdam Criteria
PCOS is diagnosed using the internationally accepted Rotterdam criteria: a diagnosis requires at least 2 of the following 3 features:
- Irregular or absent ovulation (often presenting as irregular, infrequent, or absent periods)
- Clinical or biochemical signs of hyperandrogenism (elevated testosterone or androgen markers on blood tests, or physical signs like excess hair growth, acne, or scalp hair thinning)
- Polycystic ovarian morphology on ultrasound (12 or more small follicles in each ovary, and/or increased ovarian volume)
Other conditions must first be ruled out before a PCOS diagnosis is made — including thyroid disorders, elevated prolactin, and congenital adrenal hyperplasia.
Common Symptoms
Irregular Periods
Cycles longer than 35 days, fewer than 8 periods per year, or absent periods are hallmarks of PCOS. This happens because without regular ovulation, the hormonal cycle doesn't complete properly — oestrogen builds up without the progesterone that normally follows ovulation, eventually leading to unpredictable or irregular cycles.
Excess Androgens
Elevated androgens are responsible for many of the more distressing symptoms of PCOS:
- Hirsutism: Excess dark or coarse hair on the face, chest, abdomen, or back
- Acne: Persistent hormonal acne, often along the jaw, chin, and chest
- Androgenic alopecia: Scalp hair thinning at the crown or hairline (while having excess body hair)
Insulin Resistance and Weight
Up to 70% of people with PCOS have some degree of insulin resistance — meaning cells don't respond effectively to insulin. This causes the pancreas to overproduce insulin, which in turn stimulates the ovaries to produce more androgens. This creates the core hormonal loop of PCOS.
Insulin resistance is associated with difficulty losing weight, weight gain (particularly around the abdomen), fatigue, and sugar cravings. Importantly, thin people can also have PCOS and insulin resistance — it doesn't only present in those who are overweight.
Other Common Features
- Mood changes, depression, and anxiety (significantly higher rates than the general population)
- Sleep disturbances, including sleep apnoea
- Subfertility or difficulty conceiving due to irregular ovulation
- Long-term metabolic risks if unmanaged: type 2 diabetes, elevated cholesterol, and cardiovascular disease
Management Strategies
PCOS has no cure, but its symptoms can be effectively managed through lifestyle and medical approaches. Management is highly individual — what works depends on your symptoms, goals (fertility vs. symptom management), and overall health.
Diet: Low GI and Anti-Inflammatory
The most evidence-backed dietary approach for PCOS addresses insulin resistance directly:
- Low glycaemic index (GI) eating: Prioritise complex carbohydrates that release glucose slowly — oats, legumes, sweet potatoes, most fruits, and non-starchy vegetables. Reduce refined carbohydrates, white bread, sugary drinks, and processed snacks.
- Anti-inflammatory foods: Oily fish, olive oil, turmeric, berries, leafy greens, and nuts reduce systemic inflammation that contributes to hormonal disruption.
- Adequate protein: Protein at each meal helps stabilise blood sugar. Aim for lean proteins, legumes, and fish.
Exercise
Regular physical activity is one of the most effective interventions for PCOS — it improves insulin sensitivity, supports weight management, and directly reduces androgen levels. A combination of:
- 150 minutes per week of moderate aerobic exercise (walking, cycling, swimming)
- 2–3 sessions per week of resistance training (which is particularly effective at improving insulin sensitivity)
Sleep and Stress
Chronic sleep deprivation and high stress elevate cortisol, which worsens insulin resistance. Prioritising 7–9 hours of quality sleep and regular stress-reduction practices (exercise, mindfulness, time in nature) can meaningfully improve PCOS symptoms.
Supplements with Evidence
- Inositol (myo-inositol and D-chiro-inositol): The most studied supplement for PCOS. Multiple trials show it improves insulin sensitivity, reduces androgen levels, and may restore ovulation in some people. The evidence is strongest for a 40:1 ratio of myo-inositol to D-chiro-inositol.
- Vitamin D: Deficiency is extremely common in PCOS and associated with worsened insulin resistance. Supplementing where deficient can improve metabolic and hormonal markers.
- Omega-3 fatty acids: Anti-inflammatory effects and some evidence for reducing testosterone levels.
Medical Treatments
Depending on your goals, a doctor may recommend:
- Combined oral contraceptive pill: Regulates periods, reduces androgen effects, improves acne and hirsutism. Does not treat the underlying causes of PCOS.
- Metformin: An insulin-sensitising medication that can improve cycle regularity and metabolic markers. Increasingly used in PCOS management alongside lifestyle measures.
- Letrozole or clomiphene: Ovulation-inducing medications for people with PCOS trying to conceive.
- Spironolactone: An anti-androgen medication used to manage hirsutism and acne.
Tracking Irregular Cycles with PCOS
Standard cycle tracking apps assume regular cycles — which makes them unhelpful (and potentially misleading) for people with PCOS. Mozi's irregular cycle mode focuses on symptom logging and pattern observation rather than generating predictive dates based on an assumed 28-day cycle. This makes tracking more honest and useful for understanding your cycle even when periods are unpredictable.